4L4J
Crystal structure of fc-fragment of human IgG2-Sigma antibody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ig gamma-2 chain C region | polymer | 221 | 24813.1 | 2 | UniProt (P01859) Pfam (PF07654) | Homo sapiens (human) | |
| 2 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1260.2 | 1 | In PDB GlyTouCan (G45889JQ) | |||
| 3 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 951.9 | 1 | In PDB GlyTouCan (G12045WP) | |||
| 4 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 409 | Chemie (HOH) |
Sequence modifications
A, B: 227 - 447 (UniProt: P01859)
| PDB | External Database | Details |
|---|---|---|
| Ala 235 | Val 114 | engineered mutation |
| Ala 237 | Gly 116 | engineered mutation |
| Ser 238 | Pro 117 | engineered mutation |
| Ala 268 | His 147 | engineered mutation |
| Leu 309 | Val 188 | engineered mutation |
| Ser 330 | Ala 209 | engineered mutation |
| Ser 331 | Pro 210 | engineered mutation |
| Ala 378 | Ser 257 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49626.2 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2212.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 51930.3 |
