4KPZ

Hin GlmU bound to a small molecule fragment

Summary for 4KPZ

Entry DOI	10.2210/pdb4kpz/pdb
Related	4KNR 4KNX 4KPX 4KQL
Descriptor	Bifunctional protein GlmU, 1-(3-nitrophenyl)dihydropyrimidine-2,4(1H,3H)-dione, SULFATE ION, ... (6 entities in total)
Functional Keywords	beta helix, cell wall biosynthesis, transferase
Biological source	Haemophilus influenzae
Cellular location	Cytoplasm : P43889
Total number of polymer chains	1
Total formula weight	50594.70
Authors	Doig, P.,Kazmirski, S.L.,Boriack-Sjodin, P.A. (deposition date: 2013-05-14, release date: 2014-10-15, Last modification date: 2024-02-28)
Primary citation	Doig, P.,Boriack-Sjodin, P.A.,Dumas, J.,Hu, J.,Itoh, K.,Johnson, K.,Kazmirski, S.,Kinoshita, T.,Kuroda, S.,Sato, T.O.,Sugimoto, K.,Tohyama, K.,Aoi, H.,Wakamatsu, K.,Wang, H. Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping. Bioorg.Med.Chem., 22:6256-6269, 2014 Cited by PubMed: 25262942 DOI: 10.1016/j.bmc.2014.08.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation