4KNR

Hin GlmU bound to WG188

Summary for 4KNR

Entry DOI	10.2210/pdb4knr/pdb
Related	4KNX 4KPX 4KPZ 4KQL
Descriptor	Bifunctional protein GlmU, N-{4-[(2-benzyl-7-hydroxy-6-methoxyquinazolin-4-yl)amino]phenyl}benzamide, TETRAETHYLENE GLYCOL, ... (6 entities in total)
Functional Keywords	beta helix, cell wall biosynthesis, inhibitor bound, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Haemophilus influenzae
Cellular location	Cytoplasm : P43889
Total number of polymer chains	1
Total formula weight	50739.96
Authors	Doig, P.,Kazmirski, S.L.,Boriack-Sjodin, P.A. (deposition date: 2013-05-10, release date: 2014-10-15, Last modification date: 2024-02-28)
Primary citation	Doig, P.,Boriack-Sjodin, P.A.,Dumas, J.,Hu, J.,Itoh, K.,Johnson, K.,Kazmirski, S.,Kinoshita, T.,Kuroda, S.,Sato, T.O.,Sugimoto, K.,Tohyama, K.,Aoi, H.,Wakamatsu, K.,Wang, H. Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping. Bioorg.Med.Chem., 22:6256-6269, 2014 Cited by PubMed: 25262942 DOI: 10.1016/j.bmc.2014.08.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation