4JS0

Complex of Cdc42 with the CRIB-PR domain of IRSp53

Summary for 4JS0

Entry DOI	10.2210/pdb4js0/pdb
Descriptor	Cell division control protein 42 homolog, Brain-specific angiogenesis inhibitor 1-associated protein 2, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total)
Functional Keywords	gtpase binding domain, crib domain, cytoskeleton regulation, signaling protein-signaling protein complex, signaling protein/signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P60953 Cytoplasm: Q9UQB8
Total number of polymer chains	2
Total formula weight	24739.77
Authors	Kast, D.J.,Dominguez, R. (deposition date: 2013-03-22, release date: 2014-03-05, Last modification date: 2024-02-28)
Primary citation	Kast, D.J.,Yang, C.,Disanza, A.,Boczkowska, M.,Madasu, Y.,Scita, G.,Svitkina, T.,Dominguez, R. Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors. Nat.Struct.Mol.Biol., 21:413-422, 2014 Cited by PubMed: 24584464 DOI: 10.1038/nsmb.2781 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation