4JHT

Crystal Structure of AlkB in complex with 5-carboxy-8-hydroxyquinoline (IOX1)

Summary for 4JHT

• Entry DOI: 10.2210/pdb4jht/pdb
• Related: 2FDB 2FDF 2FDG 2FDH 2FDI 2FDJ 2FDK 3BI3 3BIE 3BKZ 3H8O 3H8R 3H8X 3I2O 3I3M 3I3Q 3I49 3KHB 3KHC 3O1M 3O1O 3O1P 3O1R 3O1S 3O1T 3O1U 3O1V 3T3Y 3T4H 3T4V
• Descriptor: Alpha-ketoglutarate-dependent dioxygenase AlkB, 8-hydroxyquinoline-5-carboxylic acid, MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: double-stranded beta helix, jelly-roll motif, oxidoreductase, dioxygenase, nucleic acid demethylase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 23326.52

Authors

Aik, W.S.,McDonough, M.A.,Schofield, C.J. (deposition date: 2013-03-05, release date: 2013-06-26, Last modification date: 2023-11-08)

• Primary citation: Hopkinson, R.J.,Tumber, A.,Yapp, C.,Chowdhury, R.,Aik, W.,Che, K.H.,Li, X.S.,Kristensen, J.B.L.,King, O.N.F.,Chan, M.C.,Yeoh, K.K.,Choi, H.,Walport, L.J.,Thinnes, C.C.,Bush, J.T.,Lejeune, C.,Rydzik, A.M.,Rose, N.R.,Bagg, E.A.,McDonough, M.A.,Krojer, T.,Yue, W.W.,Ng, S.S.,Olsen, L.,Brennan, P.E.,Oppermann, U.,Muller-Knapp, S.,Klose, R.J.,Ratcliffe, P.J.,Schofield, C.J.,Kawamura, A.; 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.; Chem Sci, 4:3110-3117, 2013; PubMed: 26682036; DOI: 10.1039/C3SC51122G

Experimental method

X-RAY DIFFRACTION (1.18 Å)