4J55
Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20 with the potent antiviral inhibitor GRL-02031
Summary for 4J55
Entry DOI | 10.2210/pdb4j55/pdb |
Related | 3H5B 3UCB 3UF3 3UFN 3UHL 4J54 4J5J |
Descriptor | Protease, (3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl [(1S,2R)-1-benzyl-2-hydroxy-3-([(4-methoxyphenyl)sulfonyl]{[(2R)-5-oxopyrrolidin-2-yl]methyl}amino)propyl]carbamate (3 entities in total) |
Functional Keywords | multidrug resistant hiv-1 protease clinical isolate pr20, clinical inhibitor amprenavir, potent antiviral inhibitor grl-0519a, potent antiviral inhibitor grl-02031, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 (HIV-1) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22736.51 |
Authors | Wang, Y.-F.,Agniswamy, J.,Weber, I.T. (deposition date: 2013-02-07, release date: 2013-05-15, Last modification date: 2023-09-20) |
Primary citation | Agniswamy, J.,Shen, C.H.,Wang, Y.F.,Ghosh, A.K.,Rao, K.V.,Xu, C.X.,Sayer, J.M.,Louis, J.M.,Weber, I.T. Extreme Multidrug Resistant HIV-1 Protease with 20 Mutations Is Resistant to Novel Protease Inhibitors with P1'-Pyrrolidinone or P2-Tris-tetrahydrofuran. J.Med.Chem., 56:4017-4027, 2013 Cited by PubMed: 23590295DOI: 10.1021/jm400231v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.31 Å) |
Structure validation
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