4J5J

Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Amprenavir

Summary for 4J5J

• Entry DOI: 10.2210/pdb4j5j/pdb
• Related: 4J54 4J55
• Descriptor: Protease, CHLORIDE ION, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, ... (4 entities in total)
• Functional Keywords: multidrug resistant hiv-1 protease clinical isolate pr20, clinical inhibitor amprenavir, potent antiviral inhibitor grl-0519a, potent antiviral inhibitor grl-02031, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1 (HIV-1)
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• Total number of polymer chains: 2
• Total formula weight: 22650.70

Authors

Shen, C.H.,Weber, I.T. (deposition date: 2013-02-08, release date: 2013-05-15, Last modification date: 2023-09-20)

• Primary citation: Agniswamy, J.,Shen, C.H.,Wang, Y.F.,Ghosh, A.K.,Rao, K.V.,Xu, C.X.,Sayer, J.M.,Louis, J.M.,Weber, I.T.; Extreme Multidrug Resistant HIV-1 Protease with 20 Mutations Is Resistant to Novel Protease Inhibitors with P1'-Pyrrolidinone or P2-Tris-tetrahydrofuran.; J.Med.Chem., 56:4017-4027, 2013; PubMed: 23590295; DOI: 10.1021/jm400231v

Experimental method

X-RAY DIFFRACTION (1.8 Å)