3UCB

Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Darunavir

Summary for 3UCB

• Entry DOI: 10.2210/pdb3ucb/pdb
• Related: 3UF3 3UFN 3UHL
• Descriptor: Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1 (HIV-1)
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• Total number of polymer chains: 2
• Total formula weight: 22628.41

Authors

Agniswamy, J.,Chen-Hsiang, S.,Aniana, A.,Sayer, J.M.,Louis, J.M.,Weber, I.T. (deposition date: 2011-10-26, release date: 2012-03-28, Last modification date: 2023-09-13)

• Primary citation: Agniswamy, J.,Shen, C.H.,Aniana, A.,Sayer, J.M.,Louis, J.M.,Weber, I.T.; HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements.; Biochemistry, 51:2819-2828, 2012; PubMed: 22404139; DOI: 10.1021/bi2018317

Experimental method

X-RAY DIFFRACTION (1.38 Å)