3UHL

Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with p2-NC substrate analog

Summary for 3UHL

Entry DOI	10.2210/pdb3uhl/pdb
Related	3UCB 3UF3 3UFN
Related PRD ID	PRD_000398
Descriptor	Protease, SULFATE ION, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, ... (4 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1 (human)
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains	4
Total formula weight	44221.40
Authors	Agniswamy, J.,Chen-Hsiang, S.,Weber, I. (deposition date: 2011-11-03, release date: 2012-03-28, Last modification date: 2023-09-13)
Primary citation	Agniswamy, J.,Shen, C.H.,Aniana, A.,Sayer, J.M.,Louis, J.M.,Weber, I.T. HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements. Biochemistry, 51:2819-2828, 2012 Cited by PubMed: 22404139 DOI: 10.1021/bi2018317 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation