3UF3

Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20

Summary for 3UF3

Entry DOI	10.2210/pdb3uf3/pdb
Related	3UCB 3UFN 3UHL
Descriptor	HIV-1 protease, YTTRIUM ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	hydrolase
Biological source	Human immunodeficiency virus 1 (HIV-1)
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains	2
Total formula weight	21802.99
Authors	Agniswamy, J.,Chen-Hsiang, S.,Aniana, A.,Sayer, J.M.,Louis, J.M.,Weber, I.T. (deposition date: 2011-10-31, release date: 2012-03-28, Last modification date: 2023-09-13)
Primary citation	Agniswamy, J.,Shen, C.H.,Aniana, A.,Sayer, J.M.,Louis, J.M.,Weber, I.T. HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements. Biochemistry, 51:2819-2828, 2012 Cited by PubMed: 22404139 DOI: 10.1021/bi2018317 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation