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4IMS

Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-((5-(3-aminopropyl)-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine)

Summary for 4IMS
Entry DOI10.2210/pdb4ims/pdb
Related4IMT 4IMU 4IMW 4IMX
DescriptorNitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-{[5-(3-aminopropyl)benzene-1,3-diyl]diethane-2,1-diyl}bis(4-methylpyridin-2-amine), ... (7 entities in total)
Functional Keywordsoxidoreductase nitric oxide synthase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceRattus norvegicus (rat)
Cellular locationCell membrane, sarcolemma ; Peripheral membrane protein : P29476
Total number of polymer chains2
Total formula weight100121.28
Authors
Li, H.,Poulos, T.L. (deposition date: 2013-01-03, release date: 2013-04-24, Last modification date: 2023-09-20)
Primary citationHuang, H.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.
Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.
J.Med.Chem., 56:3024-3032, 2013
Cited by
PubMed: 23451760
DOI: 10.1021/jm4000984
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

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