4IMU

Structure of rat neuronal nitric oxide synthase in complex with 6,6'-((5-(aminomethyl)-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine)

Summary for 4IMU

Entry DOI	10.2210/pdb4imu/pdb
Related	4IMS 4IMU 4IMW 4IMX
Descriptor	Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total)
Functional Keywords	oxidoreductase nitric oxide synthase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Rattus norvegicus (rat)
Cellular location	Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476
Total number of polymer chains	2
Total formula weight	100547.67
Authors	Li, H.,Poulos, T.L. (deposition date: 2013-01-03, release date: 2013-04-24, Last modification date: 2023-09-20)
Primary citation	Huang, H.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Structure-guided design of selective inhibitors of neuronal nitric oxide synthase. J.Med.Chem., 56:3024-3032, 2013 Cited by PubMed: 23451760 DOI: 10.1021/jm4000984 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation