4IMW

Structure of rat neuronal nitric oxide synthase in complex with 3,5-bis(2-(6-amino-4-methylpyridin-2-yl)ethyl)benzonitrile

Summary for 4IMW

Entry DOI	10.2210/pdb4imw/pdb
Related	4IMS 4IMT 4IMU 4IMX
Descriptor	Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywords	oxidoreductase nitric oxide synthase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Rattus norvegicus (rat)
Cellular location	Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
Total number of polymer chains	2
Total formula weight	100266.98
Authors	Li, H.,Poulos, T.L. (deposition date: 2013-01-03, release date: 2013-04-24, Last modification date: 2023-09-20)
Primary citation	Huang, H.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Structure-guided design of selective inhibitors of neuronal nitric oxide synthase. J.Med.Chem., 56:3024-3032, 2013 Cited by PubMed: 23451760 DOI: 10.1021/jm4000984 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation