4IMT
Structure of rat neuronal nitric oxide synthase in complex with 6,6'-((4-(3-aminopropyl)-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine)
Summary for 4IMT
| Entry DOI | 10.2210/pdb4imt/pdb |
| Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
| Functional Keywords | oxidoreductase nitric oxide synthase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Rattus norvegicus (rat) |
| Cellular location | Cell membrane, sarcolemma ; Peripheral membrane protein : P29476 |
| Total number of polymer chains | 2 |
| Total formula weight | 100331.15 |
| Authors | Li, H.,Poulos, T.L. (deposition date: 2013-01-03, release date: 2013-04-24, Last modification date: 2023-09-20) |
| Primary citation | Huang, H.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Structure-guided design of selective inhibitors of neuronal nitric oxide synthase. J.Med.Chem., 56:3024-3032, 2013 Cited by PubMed: 23451760DOI: 10.1021/jm4000984 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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