4IG8

Structural basis for cytosolic double-stranded RNA surveillance by human OAS1

Summary for 4IG8

• Entry DOI: 10.2210/pdb4ig8/pdb
• Descriptor: 2'-5'-oligoadenylate synthase 1, RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*C)-3'), RNA (5'-R(*GP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3'), ... (6 entities in total)
• Functional Keywords: nucleotidyl transferase, innate immune system double-stranded dsrna sensor rna polymerase, nucleotidyl transferase 2-5a synthetase, rnase l activator, double-stranded rna, cytosol, transferase-rna complex, transferase/rna
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P00973
• Total number of polymer chains: 3
• Total formula weight: 52141.89

Authors

Donovan, J.,Korennykh, A. (deposition date: 2012-12-16, release date: 2013-01-16, Last modification date: 2024-02-28)

• Primary citation: Donovan, J.,Dufner, M.,Korennykh, A.; Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1.; Proc.Natl.Acad.Sci.USA, 110:1652-1657, 2013; PubMed: 23319625; DOI: 10.1073/pnas.1218528110

Experimental method

X-RAY DIFFRACTION (2.7 Å)