4IG8

Structural basis for cytosolic double-stranded RNA surveillance by human OAS1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016779	molecular_function	nucleotidyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 401

Chain	Residue
A	ASP75
A	ASP77
A	ASP148
A	DTP403

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 402

Chain	Residue
A	ASP75
A	ASP77
A	DTP403

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DTP A 403

Chain	Residue
A	SER74
A	ASP75
A	ASP77
A	LYS213
A	GLN229
A	MG401
A	MG402
A	HOH507
A	GLY62
A	SER63

---

Functional Information from PROSITE/UniProt

site_id	PS00832
Number of Residues	20
Details	25A_SYNTH_1 2'-5'-oligoadenylate synthases signature 1. GSsGKgTtLRgrsDaDLVvF

Chain	Residue	Details
A	GLY62-PHE81

---

site_id	PS00833
Number of Residues	11
Details	25A_SYNTH_2 2'-5'-oligoadenylate synthases signature 2. RPVILDPaDPT

Chain	Residue	Details
A	ARG295-THR305

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	57
Details	Region: {"description":"Interaction with dsRNA","evidences":[{"source":"PubMed","id":"23319625","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4IG8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23319625","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4IG8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P29728","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Interaction with dsRNA","evidences":[{"source":"PDB","id":"4IG8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---