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4I7D

Siah1 bound to synthetic peptide (ACE)KLRPVAMVRP(PRK)VR

Summary for 4I7D
Entry DOI10.2210/pdb4i7d/pdb
Related1K2F 2A25 2AN6 4I7B 4I7C
Related PRD IDPRD_000943
DescriptorE3 ubiquitin-protein ligase SIAH1, Protein phyllopod, ZINC ION, ... (5 entities in total)
Functional Keywordssina, beta sandwich, zinc finger, ubiquitin ligase, covalent inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm: Q8IUQ4
Nucleus: Q27934
Total number of polymer chains4
Total formula weight47604.20
Authors
Santelli, E.,Stebbins, J.L.,Feng, Y.,De, S.K.,Purves, A.,Motamedchaboki, K.,Wu, B.,Ronai, Z.A.,Liddington, R.C.,Pellecchia, M. (deposition date: 2012-11-30, release date: 2013-08-14, Last modification date: 2023-09-20)
Primary citationStebbins, J.L.,Santelli, E.,Feng, Y.,De, S.K.,Purves, A.,Motamedchaboki, K.,Wu, B.,Ronai, Z.A.,Liddington, R.C.,Pellecchia, M.
Structure-based design of covalent siah inhibitors.
Chem.Biol., 20:973-982, 2013
Cited by
PubMed: 23891150
DOI: 10.1016/j.chembiol.2013.06.008
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

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