4I7D

Siah1 bound to synthetic peptide (ACE)KLRPVAMVRP(PRK)VR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0007275	biological_process	multicellular organism development
A	0008270	molecular_function	zinc ion binding
C	0005737	cellular_component	cytoplasm
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0007275	biological_process	multicellular organism development
C	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACE B 112

Chain	Residue
A	PRO97
B	LYS113

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACE D 112

Chain	Residue
C	PRO97
D	LYS113

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 601

Chain	Residue
A	CYS128
A	CYS135
A	HIS147
A	HIS152

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 602

Chain	Residue
A	CYS105
A	HIS117
A	CYS121
A	CYS98

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD A 603

Chain	Residue
A	ARG231
A	ARG233
C	ALA222
C	ALA238
C	HOH732

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 601

Chain	Residue
C	CYS128
C	CYS135
C	HIS147
C	HIS152

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 602

Chain	Residue
C	CYS98
C	CYS105
C	HIS117
C	CYS121

---

site_id	AC8
Number of Residues	31
Details	BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD

Chain	Residue
A	ALA91
A	ASN92
A	SER93
A	VAL94
A	LEU95
A	PHE96
A	PRO97
A	THR108
A	CYS130
A	LEU158
A	ASP162
A	ILE163
A	VAL164
A	PHE165
A	LEU166
A	THR168
A	LEU172
A	VAL176
A	ASP177
A	TRP178
A	VAL179
A	MET180
A	GLU194
A	ARG224
A	VAL277
A	THR278
B	ACE112
B	HOH201
B	HOH202
B	HOH203
B	HOH204

---

site_id	AC9
Number of Residues	33
Details	BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD

Chain	Residue
A	SER134
C	ASN92
C	SER93
C	VAL94
C	LEU95
C	PHE96
C	THR108
C	CYS130
C	PRO131
C	THR156
C	LEU158
C	GLN159
C	GLU161
C	ASP162
C	ILE163
C	VAL164
C	PHE165
C	LEU166
C	THR168
C	PRO173
C	ALA175
C	VAL176
C	ASP177
C	TRP178
C	VAL179
C	GLU194
C	GLU197
D	ACE112
D	HOH201
D	HOH202
D	HOH203
D	HOH204
D	HOH205

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	ZN_FING: SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455

Chain	Residue	Details
A	SER93-LYS153
C	SER93-LYS153

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ

Chain	Residue	Details
A	CYS98
A	CYS105
A	HIS117
A	CYS121
C	CYS98
C	CYS105
C	HIS117
C	CYS121

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ

Chain	Residue	Details
A	CYS128
A	CYS135
A	HIS147
A	HIS152
C	CYS128
C	CYS135
C	HIS147
C	HIS152

---