4I7D
Siah1 bound to synthetic peptide (ACE)KLRPVAMVRP(PRK)VR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | E3 ubiquitin-protein ligase SIAH1 | polymer | 196 | 21976.1 | 2 | UniProt (Q8IUQ4) Pfam (PF21361) Pfam (PF03145) | Homo sapiens (human) | Seven in absentia homolog 1, Siah-1, Siah-1a |
| 2 | B, D (B, D) | Protein phyllopod | polymer | 14 | 1636.1 | 2 | UniProt (Q27934) BIRD (PRD_000943) | Drosophila melanogaster | |
| 3 | E, F, H, I (A, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | G (A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 5 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A, C: 90 - 282 (UniProt: Q8IUQ4)
B, D: 113 - 125 (UniProt: Q27934)
| PDB | External Database | Details |
|---|---|---|
| Gly 87 | - | expression tag |
| Ser 88 | - | expression tag |
| His 89 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ace 112 | - | acetylation |
| Prk 123 | Thr 123 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 47224.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 379.8 | |
| All* | Total formula weight | 47604.2 |
