4I72

Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with Immucillin A

Summary for 4I72

Entry DOI	10.2210/pdb4i72/pdb
Related	3EPW 3FZ0 4I70 4I71 4I73 4I74 4I75
Descriptor	Inosine-adenosine-guanosine-nucleoside hydrolase, CALCIUM ION, 3,4-PYRROLIDINEDIOL,2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)-2S,3S,4R,5R, ... (6 entities in total)
Functional Keywords	nucleoside hydrolase, open (alpha, beta) structure, nh fold, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Trypanosoma brucei brucei
Total number of polymer chains	2
Total formula weight	73723.14
Authors	Giannese, F.,Degano, M. (deposition date: 2012-11-30, release date: 2013-08-07, Last modification date: 2013-12-18)
Primary citation	Giannese, F.,Berg, M.,Van der Veken, P.,Castagna, V.,Tornaghi, P.,Augustyns, K.,Degano, M. Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor Acta Crystallogr.,Sect.D, 69:1553-1566, 2013 Cited by PubMed: 23897478 DOI: 10.1107/S0907444913010792 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation