4I72
Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with Immucillin A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006152 | biological_process | purine nucleoside catabolic process |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0008477 | molecular_function | purine nucleosidase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| A | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| A | 0020015 | cellular_component | glycosome |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0006152 | biological_process | purine nucleoside catabolic process |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0008477 | molecular_function | purine nucleosidase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| B | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| B | 0020015 | cellular_component | glycosome |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 401 |
| Chain | Residue |
| A | ASP10 |
| A | ASP15 |
| A | THR137 |
| A | ASP261 |
| A | UA2402 |
| A | HOH522 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE UA2 A 402 |
| Chain | Residue |
| A | ASP40 |
| A | TRP83 |
| A | THR137 |
| A | MET164 |
| A | ASN173 |
| A | GLU184 |
| A | ASN186 |
| A | GLU248 |
| A | ARG252 |
| A | TYR257 |
| A | TRP260 |
| A | ASP261 |
| A | CA401 |
| A | HOH522 |
| A | HOH526 |
| A | HOH574 |
| A | ASN12 |
| A | ASP14 |
| A | ASP15 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI A 403 |
| Chain | Residue |
| A | ASP253 |
| A | TRS406 |
| A | HOH703 |
| B | HIS58 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI A 404 |
| Chain | Residue |
| A | HIS115 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI A 405 |
| Chain | Residue |
| A | GLY-2 |
| A | SER-1 |
| A | HIS0 |
| A | MET1 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE TRS A 406 |
| Chain | Residue |
| A | ILE250 |
| A | LEU251 |
| A | ASP253 |
| A | NI403 |
| A | HOH701 |
| A | HOH702 |
| A | HOH703 |
| B | HIS58 |
| B | LEU65 |
| B | GLU82 |
| B | LYS107 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TRS A 407 |
| Chain | Residue |
| A | HIS58 |
| A | LYS107 |
| A | HOH588 |
| B | LEU251 |
| B | ASP253 |
| B | NI404 |
| B | HOH715 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE TRS A 408 |
| Chain | Residue |
| A | ASN77 |
| A | THR178 |
| A | LYS287 |
| A | HOH507 |
| A | HOH646 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 401 |
| Chain | Residue |
| B | ASP10 |
| B | ASP15 |
| B | THR137 |
| B | ASP261 |
| B | UA2402 |
| B | HOH544 |
| site_id | BC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE UA2 B 402 |
| Chain | Residue |
| B | ASN12 |
| B | ASP14 |
| B | ASP15 |
| B | ASP40 |
| B | TRP83 |
| B | THR137 |
| B | MET164 |
| B | ASN173 |
| B | GLU184 |
| B | ASN186 |
| B | GLU248 |
| B | ARG252 |
| B | TYR257 |
| B | TRP260 |
| B | ASP261 |
| B | CA401 |
| B | HOH508 |
| B | HOH544 |
| B | HOH611 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NI B 403 |
| Chain | Residue |
| B | HIS115 |
| B | HOH696 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI B 404 |
| Chain | Residue |
| A | HIS58 |
| A | TRS407 |
| B | ASP253 |
| B | HOH715 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI B 405 |
| Chain | Residue |
| B | GLY-2 |
| B | SER-1 |
| B | HIS0 |
| B | MET1 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI B 406 |
| Chain | Residue |
| B | HIS317 |
