4I5L

Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation

4I5L の概要

• エントリーDOI: 10.2210/pdb4i5l/pdb
• 関連するPDBエントリー: 2IE3 2NPP 3P71 4I5J 4I5K 4I5N
• 関連するBIRD辞書のPRD_ID: PRD_001031
• 分子名称: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Cell division control protein 6 homolog chimeric construct, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, ... (9 entities in total)
• 機能のキーワード: ef hand, phosphatase, cdc6 (substrate), hydrolase-toxin complex, hydrolase/toxin
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm : P30153 P67775; Nucleus : Q99741
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 299714.82

構造登録者

Wlodarchak, N.,Satyshur, K.A.,Guo, F.,Xing, Y. (登録日: 2012-11-28, 公開日: 2013-05-08, 最終更新日: 2023-11-15)

• 主引用文献: Wlodarchak, N.,Guo, F.,Satyshur, K.A.,Jiang, L.,Jeffrey, P.D.,Sun, T.,Stanevich, V.,Mumby, M.C.,Xing, Y.; Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.; Cell Res., 23:931-946, 2013; PubMed: 23752926; DOI: 10.1038/cr.2013.77

実験手法

X-RAY DIFFRACTION (2.43 Å)