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4I5N

Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation

Summary for 4I5N
Entry DOI10.2210/pdb4i5n/pdb
Related2IE3 2NPP 3P71 4I5J 4I5K 4I5L
Related PRD IDPRD_001031
DescriptorSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Cell division control protein 6 homolog chimeric construct, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, ... (7 entities in total)
Functional Keywordsef hand, phosphatase, cdc6 (substrate), transferase-toxin complex, hydrolase-toxin complex, hydrolase/toxin
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm : P30153 P67775
Nucleus : Q99741
Total number of polymer chains8
Total formula weight300398.55
Authors
Wlodarchak, N.,Satyshur, K.A.,Guo, F.,Xing, Y. (deposition date: 2012-11-28, release date: 2013-05-08, Last modification date: 2023-11-15)
Primary citationWlodarchak, N.,Guo, F.,Satyshur, K.A.,Jiang, L.,Jeffrey, P.D.,Sun, T.,Stanevich, V.,Mumby, M.C.,Xing, Y.
Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.
Cell Res., 23:931-946, 2013
Cited by
PubMed: 23752926
DOI: 10.1038/cr.2013.77
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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