4I5N
Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | polymer | 584 | 65563.5 | 2 | UniProt (P30153) Pfam (PF02985) | Homo sapiens (human) | Medium tumor antigen-associated 61 kDa protein, PP2A subunit A isoform PR65-alpha, PP2A subunit A isoform R1-alpha |
| 2 | B, E (B, E) | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Cell division control protein 6 homolog chimeric construct | polymer | 413 | 47649.3 | 2 | UniProt (Q9Y5P8) UniProt (Q99741) Pfam (PF21161) Pfam (PF17958) Pfam (PF13499) | Homo sapiens (human) | PP2A subunit B isoform PR48 Protein phosphatase 2A 48 kDa regulatory subunit |
| 3 | C, F (C, F) | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha | polymer | 311 | 35780.3 | 2 | UniProt (P67775) Pfam (PF00149) | Homo sapiens (human) | |
| 4 | G, H (G, H) | Microcystin-LR (MCLR) bound form | polymer | 7 | 1016.2 | 2 | BIRD (PRD_001031) | Microcystis aeruginosa | |
| 5 | I, J, M, N (B, E) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 6 | K, L, O, P (C, F) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 7 | Q, R, S, T, U... (A, B, C, D, E...) | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence modifications
B, E: 122 - 490 (UniProt: Q9Y5P8)
B, E: 512 - 532 (UniProt: Q99741)
| PDB | External Database | Details |
|---|---|---|
| Ser 491 | - | linker |
| Thr 492 | - | linker |
| Gly 493 | - | linker |
| Asn 494 | - | linker |
| Ala 495 | - | linker |
| Ser 496 | - | linker |
| Asp 497 | - | linker |
| Ser 498 | - | linker |
| Ser 499 | - | linker |
| Ser 500 | - | linker |
| Asp 501 | - | linker |
| Ser 502 | - | linker |
| Ser 503 | - | linker |
| Ser 504 | - | linker |
| Ser 505 | - | linker |
| Glu 506 | - | linker |
| Gly 507 | - | linker |
| Asp 508 | - | linker |
| Gly 509 | - | linker |
| Thr 510 | - | linker |
| Val 511 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 300018.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 380.1 | |
| All* | Total formula weight | 300398.5 |
