4HJT

Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)phenyl)propionamide

4HJT の概要

• エントリーDOI: 10.2210/pdb4hjt/pdb
• 関連するPDBエントリー: 3CN0 3CN1 3HJO 3IMR 3IMT 4HJS 4HJU
• 分子名称: Transthyretin, N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}propanamide (3 entities in total)
• 機能のキーワード: hormone binding protein, thyroxine, retinol binding protein, hormone binding protein-inhibitor complex, hormone binding protein/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02766
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28145.47

構造登録者

Connelly, S.,Wilson, I.A. (登録日: 2012-10-14, 公開日: 2013-12-04, 最終更新日: 2024-10-09)

• 主引用文献: Suh, E.H.,Liu, Y.,Connelly, S.,Genereux, J.C.,Wilson, I.A.,Kelly, J.W.; Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis.; J.Am.Chem.Soc., 135:17869-17880, 2013; PubMed: 24180271; DOI: 10.1021/ja408230k

実験手法

X-RAY DIFFRACTION (1.45 Å)