4H2B

Human ecto-5'-nucleotidase (CD73): crystal form II (open) in complex with Baicalin

Summary for 4H2B

Entry DOI	10.2210/pdb4h2b/pdb
Related	4H1Y 4h2f 4h2g 4h2i
Descriptor	5'-nucleotidase, ZINC ION, 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, ... (6 entities in total)
Functional Keywords	dimer, hydrolase phosphatase nucleotidase, extracellular, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Lipid-anchor, GPI-anchor: P21589
Total number of polymer chains	1
Total formula weight	61214.16
Authors	Zebisch, M.,Pippel, J.,Knapp, K.,Straeter, N. (deposition date: 2012-09-12, release date: 2012-11-28, Last modification date: 2012-12-26)
Primary citation	Knapp, K.,Zebisch, M.,Pippel, J.,El-Tayeb, A.,Muller, C.E.,Strater, N. Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling. Structure, 20:2161-2173, 2012 Cited by PubMed: 23142347 DOI: 10.1016/j.str.2012.10.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation