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4H1Y

Human ecto-5'-nucleotidase (CD73): crystal form II (open) in complex with PSB11552

Summary for 4H1Y
Entry DOI10.2210/pdb4h1y/pdb
Related4H2B 4h2f 4h2g 4h2i
Descriptor5'-nucleotidase, ZINC ION, 2,2'-[(2-{[2-({[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]carbonyl}amino)ethyl]amino}-2-oxoethyl)imino]diacetic acid (non-preferred name), ... (7 entities in total)
Functional Keywordsdimeric, nucleotidase, hydrolase, amp binding, zinc binding, extracellular
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Lipid-anchor, GPI-anchor: P21589
Total number of polymer chains1
Total formula weight61236.17
Authors
Pippel, J.,Zebisch, M.,Knapp, K.,Straeter, N. (deposition date: 2012-09-11, release date: 2012-11-28, Last modification date: 2017-11-15)
Primary citationKnapp, K.,Zebisch, M.,Pippel, J.,El-Tayeb, A.,Muller, C.E.,Strater, N.
Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
Structure, 20:2161-2173, 2012
Cited by
PubMed: 23142347
DOI: 10.1016/j.str.2012.10.001
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.58 Å)
Structure validation

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