4H1Y

Human ecto-5'-nucleotidase (CD73): crystal form II (open) in complex with PSB11552

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0000166	molecular_function	nucleotide binding
P	0002953	molecular_function	5'-deoxynucleotidase activity
P	0005515	molecular_function	protein binding
P	0005886	cellular_component	plasma membrane
P	0006196	biological_process	AMP catabolic process
P	0007159	biological_process	leukocyte cell-cell adhesion
P	0008253	molecular_function	5'-nucleotidase activity
P	0008270	molecular_function	zinc ion binding
P	0009166	biological_process	nucleotide catabolic process
P	0009897	cellular_component	external side of plasma membrane
P	0009986	cellular_component	cell surface
P	0010035	biological_process	obsolete response to inorganic substance
P	0016020	cellular_component	membrane
P	0016787	molecular_function	hydrolase activity
P	0016788	molecular_function	hydrolase activity, acting on ester bonds
P	0031214	biological_process	biomineral tissue development
P	0033198	biological_process	response to ATP
P	0042802	molecular_function	identical protein binding
P	0046032	biological_process	ADP catabolic process
P	0046034	biological_process	ATP metabolic process
P	0046872	molecular_function	metal ion binding
P	0055074	biological_process	calcium ion homeostasis
P	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN P 601

Chain	Residue
P	ASP36
P	ASP85
P	ASN117
P	HIS220
P	HIS243
P	ZN602
P	HOH733

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN P 602

Chain	Residue
P	ASP85
P	ZN601
P	HOH733
P	HOH769
P	HOH1055
P	ASP36
P	HIS38

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 0YQ P 603

Chain	Residue
P	GLN231
P	ASP270
P	ARG354
P	ASN390
P	GLY392
P	GLY393
P	ARG395
P	PHE417
P	GLY447
P	PHE500
P	ASP506
P	HOH954
P	HOH1082

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL P 604

Chain	Residue
P	TYR96
P	LYS326
P	LYS330
P	LYS464
P	HOH957

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL P 605

Chain	Residue
P	PHE223
P	GLU224
P	HOH971
P	HOH977
P	HOH1314

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P 606

Chain	Residue
P	ASN213
P	ASP237
P	GLY298
P	HOH734
P	HOH892
P	HOH1081

---

Functional Information from PROSITE/UniProt

site_id	PS00785
Number of Residues	13
Details	5_NUCLEOTIDASE_1 5'-nucleotidase signature 1. LtILHTnDvHSrL

Chain	Residue	Details
P	LEU29-LEU41

---

site_id	PS00786
Number of Residues	12
Details	5_NUCLEOTIDASE_2 5'-nucleotidase signature 2. YdamaLGNHEFD

Chain	Residue	Details
P	TYR110-ASP121

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22997138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34403084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4H1S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22997138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34403084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4H1S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22997138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34403084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4H1S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34403084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PBA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Lipidation: {"description":"GPI-anchor amidated serine","evidences":[{"source":"PubMed","id":"2129526","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22997138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---