4H2B
Human ecto-5'-nucleotidase (CD73): crystal form II (open) in complex with Baicalin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5'-nucleotidase | polymer | 547 | 60561.4 | 1 | UniProt (P21589) Pfam (PF00149) Pfam (PF02872) | Homo sapiens (human) | 5'-NT, Ecto-5'-nucleotidase |
| 2 | B, C (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D (A) | 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid | non-polymer | 446.4 | 1 | Chemie (0XE) PubChem (22524511) PubChem (64982) PubChem (42433515) PubChem (42433517) PubChem (44258403) PubChem (44298962) PubChem (24211960) PubChem (40484442) PubChem (42433519) PubChem (51521825) PubChem (51708723) PubChem (51708725) PubChem (44578018) PubChem (1549028) PubChem (51340228) PubChem (51521823) PubChem (69717682) PubChem (69754005) PubChem (5321495) PubChem (73265236) PubChem (6347542) PubChem (6560193) PubChem (89187871) PubChem (93956873) PubChem (93956874) PubChem (3807559) PubChem (98619489) PubChem (99720142) PubChem (121475731) PubChem (131801318) PubChem (124632415) PubChem (13654833) PubChem (146496290) PubChem (162906866) PubChem (168011974) PubChem (16212402) | |||
| 4 | E (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) PubChem (271) | |||
| 5 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 6 | G (A) | water | water | 18.0 | 406 | Chemie (HOH) |
Sequence modifications
A: 27 - 549 (UniProt: P21589)
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | initiating methionine |
| Ala 4 | - | expression tag |
| His 5 | - | expression tag |
| His 6 | - | expression tag |
| His 7 | - | expression tag |
| His 8 | - | expression tag |
| His 9 | - | expression tag |
| His 10 | - | expression tag |
| Val 11 | - | expression tag |
| Gly 12 | - | expression tag |
| Thr 13 | - | expression tag |
| Gly 14 | - | expression tag |
| Ser 15 | - | expression tag |
| Asn 16 | - | expression tag |
| Asp 17 | - | expression tag |
| Asp 18 | - | expression tag |
| Asp 19 | - | expression tag |
| Asp 20 | - | expression tag |
| Lys 21 | - | expression tag |
| Ser 22 | - | expression tag |
| Pro 23 | - | expression tag |
| Asp 24 | - | expression tag |
| Pro 25 | - | expression tag |
| Pro 26 | - | expression tag |
| Asp 53 | Asn 53 | engineered mutation |
| Ser 145 | Lys 145 | engineered mutation |
| Ser 147 | Lys 147 | engineered mutation |
| Asp 311 | Asn 311 | engineered mutation |
| Asp 333 | Asn 333 | engineered mutation |
| Ala 376 | Thr 376 | variant |
| Asp 403 | Asn 403 | engineered mutation |
| Ser 478 | Lys 478 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 60561.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 652.7 | |
| All* | Total formula weight | 61214.2 |
