4GVJ
Tyk2 (JH1) in complex with adenosine di-phosphate
Summary for 4GVJ
Entry DOI | 10.2210/pdb4gvj/pdb |
Related | 4GFM 4GFO 4GIH 4GII 4GJ2 4GJ3 4GMY |
Descriptor | Non-receptor tyrosine-protein kinase TYK2, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | kinase, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 35225.53 |
Authors | Liang, J.,Abbema, A.V.,Bao, L.,Barrett, K.,Beresini, M.,Berezhkovskiy, L.,Blair, W.,Chang, C.,Driscoll, J.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,Halladay, J.,Johnson, A.,Kohli, P.B.,Lai, Y.,Liimatta, M.,Mantik, P.,Menghrajani, K.,Murray, J.,Sambrone, A.,Shao, Y.,Shia, S.,Shin, Y.,Smith, J.,Sohn, S.,Stanley, M.,Tsui, V.,Ultsch, M.,Wu, L.,Zhang, B.,Magnuson, S. (deposition date: 2012-08-30, release date: 2013-08-14, Last modification date: 2023-09-13) |
Primary citation | Liang, J.,Tsui, V.,Van Abbema, A.,Bao, L.,Barrett, K.,Beresini, M.,Berezhkovskiy, L.,Blair, W.S.,Chang, C.,Driscoll, J.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,Halladay, J.,Johnson, A.,Kohli, P.B.,Lai, Y.,Liimatta, M.,Mantik, P.,Menghrajani, K.,Murray, J.,Sambrone, A.,Xiao, Y.,Shia, S.,Shin, Y.,Smith, J.,Sohn, S.,Stanley, M.,Ultsch, M.,Zhang, B.,Wu, L.C.,Magnuson, S. Lead identification of novel and selective TYK2 inhibitors. Eur.J.Med.Chem., 67:175-187, 2013 Cited by PubMed: 23867602DOI: 10.1016/j.ejmech.2013.03.070 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
Download full validation report