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4GUY

Human MMP12 catalytic domain in complex with*N*-Hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide

Replaces:  3RTU
Summary for 4GUY
Entry DOI10.2210/pdb4guy/pdb
Related3F15 3F16 3F17 3F1A 3LK8 3NX7
DescriptorMacrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywordsmmp-12, matrix, metalloproteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix : P39900
Total number of polymer chains1
Total formula weight18023.85
Authors
Calderone, V.,Fragai, M.,Luchinat, C.,Massaro, A.,Mordini, A.,Mori, M. (deposition date: 2012-08-30, release date: 2012-09-19, Last modification date: 2023-11-08)
Primary citationMori, M.,Massaro, A.,Calderone, V.,Fragai, M.,Luchinat, C.,Mordini, A.
Contribution of free energy of solvation to ligand affinity in new potent MMPs inhibitors.
To be Published,
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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