Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

4GUY

Human MMP12 catalytic domain in complex with*N*-Hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide

Replaces:  3RTU
Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0031012cellular_componentextracellular matrix
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 301
ChainResidue
AHIS218
AHIS222
AHIS228
AKLJ306

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 302
ChainResidue
AHIS168
AASP170
AHIS183
AHIS196

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 303
ChainResidue
AGLY190
AGLY192
AASP194
AHOH433
AASP158

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 304
ChainResidue
AASP124
AGLU199
AGLU201
AHOH412

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 305
ChainResidue
AASP175
AGLY176
AGLY178
AILE180
AASP198
AGLU201

site_idAC6
Number of Residues13
DetailsBINDING SITE FOR RESIDUE KLJ A 306
ChainResidue
AGLY179
ALEU181
AALA182
AHIS218
AGLU219
AHIS222
AHIS228
AVAL235
APHE237
APRO238
ATHR239
AZN301
AHOH475

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAVHEIGHSL
ChainResidueDetails
ATHR215-LEU224

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE:
ChainResidueDetails
AGLU219

site_idSWS_FT_FI2
Number of Residues19
DetailsBINDING:
ChainResidueDetails
AASP124
AGLY190
AGLY192
AASP194
AHIS196
AASP198
AGLU199
AGLU201
AHIS218
AHIS222
AHIS228
AASP158
AHIS168
AASP170
AASP175
AGLY176
AGLY178
AILE180
AHIS183

229183

PDB entries from 2024-12-18

PDB statisticsPDBj update infoContact PDBjnumon