3NX7

Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-Hydroxy-2-(N-(2-hydroxyethyl)4-methoxyphenylsulfonamido)acetamide

Summary for 3NX7

Entry DOI	10.2210/pdb3nx7/pdb
Related	3F15 3F16 3F17 3F19 3F1A
Descriptor	Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	matrix metalloproteinase, mmp12, elastase, complex (elastase-inhibitor), hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P39900
Total number of polymer chains	1
Total formula weight	18039.85
Authors	Bertini, I.,Calderone, V.,Fragai, M.,Giachetti, A.,Loconte, M.,Luchinat, C.,Maletta, M.,Nativi, C.,Yeo, K.J. (deposition date: 2010-07-13, release date: 2010-07-28, Last modification date: 2023-09-06)
Primary citation	Bertini, I.,Calderone, V.,Fragai, M.,Giachetti, A.,Loconte, M.,Luchinat, C.,Maletta, M.,Nativi, C.,Yeo, K.J. Exploring the subtleties of drug-receptor interactions: the case of matrix metalloproteinases J.Am.Chem.Soc., 129:2466-2475, 2007 Cited by PubMed: 17269766 DOI: 10.1021/ja065156z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation