3NX7

Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-Hydroxy-2-(N-(2-hydroxyethyl)4-methoxyphenylsulfonamido)acetamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 264

Chain	Residue
A	NHK0
A	HIS218
A	HIS222
A	HIS228

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 265

Chain	Residue
A	HIS168
A	ASP170
A	HIS183
A	HIS196

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 266

Chain	Residue
A	ASP158
A	GLY190
A	GLY192
A	ASP194
A	HOH11

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 267

Chain	Residue
A	HOH16
A	HOH72
A	ASP124
A	GLU199
A	GLU201

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 268

Chain	Residue
A	ASP175
A	GLY176
A	GLY178
A	ILE180
A	ASP198
A	GLU201

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE NHK A 0

Chain	Residue
A	HOH4
A	GLY179
A	ILE180
A	LEU181
A	ALA182
A	THR215
A	HIS218
A	GLU219
A	HIS222
A	HIS228
A	PRO238
A	TYR240
A	ZN264

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAVHEIGHSL

Chain	Residue	Details
A	THR215-LEU224

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	19
Details	Binding site: {}

Chain

Residue

Details

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