4GE9

Kynurenine Aminotransferase II Inhibitors

Summary for 4GE9

Entry DOI	10.2210/pdb4ge9/pdb
Related	3UE8 4GDY 4GE4 4GE7 4GEB
Descriptor	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, (4-{[(6-benzyl-1-hydroxy-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)amino]methyl}-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (3 entities in total)
Functional Keywords	aminotransferase, irreversible inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion (Potential): Q8N5Z0
Total number of polymer chains	4
Total formula weight	197910.15
Authors	Pandit, J. (deposition date: 2012-08-01, release date: 2012-11-07, Last modification date: 2024-02-28)
Primary citation	Tuttle, J.B.,Anderson, M.,Bechle, B.M.,Campbell, B.M.,Chang, C.,Dounay, A.B.,Evrard, E.,Fonseca, K.R.,Gan, X.,Ghosh, S.,Horner, W.,James, L.C.,Kim, J.Y.,McAllister, L.A.,Pandit, J.,Parikh, V.D.,Rago, B.J.,Salafia, M.A.,Strick, C.A.,Zawadzke, L.E.,Verhoest, P.R. Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett, 4:37-40, 2013 Cited by PubMed: 24900560 DOI: 10.1021/ml300237v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.43 Å)

Structure validation