4GDY
Kynurenine Aminotransferase II inhibitors
Summary for 4GDY
Entry DOI | 10.2210/pdb4gdy/pdb |
Related | 3UE8 4GE4 4GE7 4GE9 4GEB |
Descriptor | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, (5-hydroxy-6-methyl-4-{[(1-oxo-7-phenoxy-1,2-dihydro[1,2,4]triazolo[4,3-a]quinolin-4-yl)amino]methyl}pyridin-3-yl)methyl dihydrogen phosphate (3 entities in total) |
Functional Keywords | aminotransferase, pyridoxal phosphate co-factor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion (Potential): Q8N5Z0 |
Total number of polymer chains | 2 |
Total formula weight | 98947.02 |
Authors | Pandit, J. (deposition date: 2012-08-01, release date: 2012-08-29, Last modification date: 2023-09-13) |
Primary citation | Verhoest, P.R.,Henderson, J.L.,Sawant-Basak, A.,Tuttle, J.B.,Dounay, A.B.,McAllister, L.A.,Pandit, J.,Rong, S.,Hou, X.,Bechle, B.,Parikh, V.,Evrard, E.,Ghosh, S.,Salafia, M.A.,Rago, B.,Obach, R.,Fonseca, K.R.,Chang, C. Discovery of Hydroxamate Bioisosteres as KATII Inhibitors with Improved Oral Bioavailability and Pharmacokinetics MEDCHEMCOMM, 2012 Cited by DOI: 10.1039/C2MD20166FPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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