4GDY
Kynurenine Aminotransferase II inhibitors
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | polymer | 439 | 48950.1 | 2 | UniProt (Q8N5Z0) Pfam (PF00155) In PDB | Homo sapiens (human) | KAT/AadAT, 2-aminoadipate aminotransferase, 2-aminoadipate transaminase, Alpha-aminoadipate aminotransferase, AadAT, Kynurenine aminotransferase II, Kynurenine--oxoglutarate aminotransferase II, Kynurenine--oxoglutarate transaminase 2, Kynurenine--oxoglutarate transaminase II |
2 | A, B | (5-hydroxy-6-methyl-4-{[(1-oxo-7-phenoxy-1,2-dihydro[1,2,4]triazolo[4,3-a]quinolin-4-yl)amino]methyl}pyridin-3-yl)methyl dihydrogen phosphate | non-polymer | 523.4 | 2 | Chemie (0X1) | |||
3 | water | water | 18.0 | 217 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 425 (UniProt: Q8N5Z0)
PDB | External Database | Details |
---|---|---|
Ser 240 | Lys 240 | engineered mutation |
Gly 241 | Phe 241 | engineered mutation |
Leu 426 | - | expression tag |
Val 427 | - | expression tag |
Pro 428 | - | expression tag |
Arg 429 | - | expression tag |
Gly 430 | - | expression tag |
Ser 431 | - | expression tag |
Leu 432 | - | expression tag |
Glu 433 | - | expression tag |
His 434 | - | expression tag |
His 435 | - | expression tag |
His 436 | - | expression tag |
His 437 | - | expression tag |
His 438 | - | expression tag |
His 439 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 97900.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1046.9 | |
All* | Total formula weight | 98947.0 |