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4GE9

Kynurenine Aminotransferase II Inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006103biological_process2-oxoglutarate metabolic process
A0006536biological_processglutamate metabolic process
A0008483molecular_functiontransaminase activity
A0009058biological_processbiosynthetic process
A0016212molecular_functionkynurenine-oxoglutarate transaminase activity
A0030170molecular_functionpyridoxal phosphate binding
A0033512biological_processL-lysine catabolic process to acetyl-CoA via saccharopine
A0042803molecular_functionprotein homodimerization activity
A0047315molecular_functionkynurenine-glyoxylate transaminase activity
A0047536molecular_function2-aminoadipate transaminase activity
A0047958molecular_functionglycine:2-oxoglutarate aminotransferase activity
A0050094molecular_functionmethionine-glyoxylate transaminase activity
A0070189biological_processkynurenine metabolic process
A1901605biological_processalpha-amino acid metabolic process
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0006103biological_process2-oxoglutarate metabolic process
B0006536biological_processglutamate metabolic process
B0008483molecular_functiontransaminase activity
B0009058biological_processbiosynthetic process
B0016212molecular_functionkynurenine-oxoglutarate transaminase activity
B0030170molecular_functionpyridoxal phosphate binding
B0033512biological_processL-lysine catabolic process to acetyl-CoA via saccharopine
B0042803molecular_functionprotein homodimerization activity
B0047315molecular_functionkynurenine-glyoxylate transaminase activity
B0047536molecular_function2-aminoadipate transaminase activity
B0047958molecular_functionglycine:2-oxoglutarate aminotransferase activity
B0050094molecular_functionmethionine-glyoxylate transaminase activity
B0070189biological_processkynurenine metabolic process
B1901605biological_processalpha-amino acid metabolic process
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0006103biological_process2-oxoglutarate metabolic process
C0006536biological_processglutamate metabolic process
C0008483molecular_functiontransaminase activity
C0009058biological_processbiosynthetic process
C0016212molecular_functionkynurenine-oxoglutarate transaminase activity
C0030170molecular_functionpyridoxal phosphate binding
C0033512biological_processL-lysine catabolic process to acetyl-CoA via saccharopine
C0042803molecular_functionprotein homodimerization activity
C0047315molecular_functionkynurenine-glyoxylate transaminase activity
C0047536molecular_function2-aminoadipate transaminase activity
C0047958molecular_functionglycine:2-oxoglutarate aminotransferase activity
C0050094molecular_functionmethionine-glyoxylate transaminase activity
C0070189biological_processkynurenine metabolic process
C1901605biological_processalpha-amino acid metabolic process
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0006103biological_process2-oxoglutarate metabolic process
D0006536biological_processglutamate metabolic process
D0008483molecular_functiontransaminase activity
D0009058biological_processbiosynthetic process
D0016212molecular_functionkynurenine-oxoglutarate transaminase activity
D0030170molecular_functionpyridoxal phosphate binding
D0033512biological_processL-lysine catabolic process to acetyl-CoA via saccharopine
D0042803molecular_functionprotein homodimerization activity
D0047315molecular_functionkynurenine-glyoxylate transaminase activity
D0047536molecular_function2-aminoadipate transaminase activity
D0047958molecular_functionglycine:2-oxoglutarate aminotransferase activity
D0050094molecular_functionmethionine-glyoxylate transaminase activity
D0070189biological_processkynurenine metabolic process
D1901605biological_processalpha-amino acid metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE 0L0 A 4000
ChainResidue
ASER117
ASER262
ALYS263
AARG270
APHE355
AARG399
AHOH4387
BILE19
BARG20
BTHR23
BGLY39
AGLN118
BTYR74
BSER75
BSER77
ATYR142
AVAL197
AASN202
AASP230
APRO232
ATYR233
ASER260

site_idAC2
Number of Residues25
DetailsBINDING SITE FOR RESIDUE 0L0 B 4000
ChainResidue
AILE19
AARG20
ATHR23
AGLY39
ALEU40
ATYR74
ASER75
ASER77
ALEU293
BSER117
BGLN118
BTYR142
BVAL197
BASN202
BASP230
BPRO232
BTYR233
BSER260
BSER262
BLYS263
BARG270
BPHE355
BARG399
BHOH4113
BHOH4260

site_idAC3
Number of Residues24
DetailsBINDING SITE FOR RESIDUE 0L0 C 4000
ChainResidue
CSER117
CGLN118
CTYR142
CVAL197
CASN202
CASP230
CPRO232
CTYR233
CSER260
CSER262
CLYS263
CARG270
CPHE355
CARG399
CHOH4163
DILE19
DARG20
DTHR23
DGLY39
DLEU40
DTYR74
DSER75
DSER77
DLEU293

site_idAC4
Number of Residues22
DetailsBINDING SITE FOR RESIDUE 0L0 D 4000
ChainResidue
CILE19
CARG20
CTHR23
CGLY39
CTYR74
CSER75
CSER77
CLEU293
DSER117
DGLN118
DTYR142
DVAL197
DASN202
DASP230
DPRO232
DTYR233
DSER260
DSER262
DLYS263
DARG270
DPHE355
DARG399

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsBINDING:
ChainResidueDetails
AARG20
BARG399
CARG20
CTYR74
CTYR142
CASN202
CARG399
DARG20
DTYR74
DTYR142
DASN202
ATYR74
DARG399
ATYR142
AASN202
AARG399
BARG20
BTYR74
BTYR142
BASN202

site_idSWS_FT_FI2
Number of Residues12
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9WVM8
ChainResidueDetails
ALYS69
DLYS69
DLYS179
DLYS422
ALYS179
ALYS422
BLYS69
BLYS179
BLYS422
CLYS69
CLYS179
CLYS422

site_idSWS_FT_FI3
Number of Residues12
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9WVM8
ChainResidueDetails
ALYS263
DLYS263
DLYS339
DLYS367
ALYS339
ALYS367
BLYS263
BLYS339
BLYS367
CLYS263
CLYS339
CLYS367

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PDB entries from 2024-11-06

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