Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4GE9

Kynurenine Aminotransferase II Inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0008483	molecular_function	transaminase activity
A	0009058	biological_process	biosynthetic process
A	0009063	biological_process	amino acid catabolic process
A	0016212	molecular_function	L-kynurenine:2-oxoglutarate transaminase activity
A	0019477	biological_process	L-lysine catabolic process
A	0030170	molecular_function	pyridoxal phosphate binding
A	0047313	molecular_function	aromatic-amino-acid:glyoxylate transaminase activity
A	0047315	molecular_function	L-kynurenine:glyoxylate transaminase activity
A	0047536	molecular_function	L-2-aminoadipate:2-oxoglutarate transaminase activity
A	0047958	molecular_function	glycine:2-oxoglutarate transaminase activity
A	0050094	molecular_function	L-methionine:glyoxylate transaminase activity
A	1901605	biological_process	alpha-amino acid metabolic process
A	1901606	biological_process	alpha-amino acid catabolic process
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0008483	molecular_function	transaminase activity
B	0009058	biological_process	biosynthetic process
B	0009063	biological_process	amino acid catabolic process
B	0016212	molecular_function	L-kynurenine:2-oxoglutarate transaminase activity
B	0019477	biological_process	L-lysine catabolic process
B	0030170	molecular_function	pyridoxal phosphate binding
B	0047313	molecular_function	aromatic-amino-acid:glyoxylate transaminase activity
B	0047315	molecular_function	L-kynurenine:glyoxylate transaminase activity
B	0047536	molecular_function	L-2-aminoadipate:2-oxoglutarate transaminase activity
B	0047958	molecular_function	glycine:2-oxoglutarate transaminase activity
B	0050094	molecular_function	L-methionine:glyoxylate transaminase activity
B	1901605	biological_process	alpha-amino acid metabolic process
B	1901606	biological_process	alpha-amino acid catabolic process
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0008483	molecular_function	transaminase activity
C	0009058	biological_process	biosynthetic process
C	0009063	biological_process	amino acid catabolic process
C	0016212	molecular_function	L-kynurenine:2-oxoglutarate transaminase activity
C	0019477	biological_process	L-lysine catabolic process
C	0030170	molecular_function	pyridoxal phosphate binding
C	0047313	molecular_function	aromatic-amino-acid:glyoxylate transaminase activity
C	0047315	molecular_function	L-kynurenine:glyoxylate transaminase activity
C	0047536	molecular_function	L-2-aminoadipate:2-oxoglutarate transaminase activity
C	0047958	molecular_function	glycine:2-oxoglutarate transaminase activity
C	0050094	molecular_function	L-methionine:glyoxylate transaminase activity
C	1901605	biological_process	alpha-amino acid metabolic process
C	1901606	biological_process	alpha-amino acid catabolic process
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0008483	molecular_function	transaminase activity
D	0009058	biological_process	biosynthetic process
D	0009063	biological_process	amino acid catabolic process
D	0016212	molecular_function	L-kynurenine:2-oxoglutarate transaminase activity
D	0019477	biological_process	L-lysine catabolic process
D	0030170	molecular_function	pyridoxal phosphate binding
D	0047313	molecular_function	aromatic-amino-acid:glyoxylate transaminase activity
D	0047315	molecular_function	L-kynurenine:glyoxylate transaminase activity
D	0047536	molecular_function	L-2-aminoadipate:2-oxoglutarate transaminase activity
D	0047958	molecular_function	glycine:2-oxoglutarate transaminase activity
D	0050094	molecular_function	L-methionine:glyoxylate transaminase activity
D	1901605	biological_process	alpha-amino acid metabolic process
D	1901606	biological_process	alpha-amino acid catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE 0L0 A 4000

Chain	Residue
A	SER117
A	SER262
A	LYS263
A	ARG270
A	PHE355
A	ARG399
A	HOH4387
B	ILE19
B	ARG20
B	THR23
B	GLY39
A	GLN118
B	TYR74
B	SER75
B	SER77
A	TYR142
A	VAL197
A	ASN202
A	ASP230
A	PRO232
A	TYR233
A	SER260

site_id	AC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE 0L0 B 4000

Chain	Residue
A	ILE19
A	ARG20
A	THR23
A	GLY39
A	LEU40
A	TYR74
A	SER75
A	SER77
A	LEU293
B	SER117
B	GLN118
B	TYR142
B	VAL197
B	ASN202
B	ASP230
B	PRO232
B	TYR233
B	SER260
B	SER262
B	LYS263
B	ARG270
B	PHE355
B	ARG399
B	HOH4113
B	HOH4260

site_id	AC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE 0L0 C 4000

Chain	Residue
C	SER117
C	GLN118
C	TYR142
C	VAL197
C	ASN202
C	ASP230
C	PRO232
C	TYR233
C	SER260
C	SER262
C	LYS263
C	ARG270
C	PHE355
C	ARG399
C	HOH4163
D	ILE19
D	ARG20
D	THR23
D	GLY39
D	LEU40
D	TYR74
D	SER75
D	SER77
D	LEU293

site_id	AC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE 0L0 D 4000

Chain	Residue
C	ILE19
C	ARG20
C	THR23
C	GLY39
C	TYR74
C	SER75
C	SER77
C	LEU293
D	SER117
D	GLN118
D	TYR142
D	VAL197
D	ASN202
D	ASP230
D	PRO232
D	TYR233
D	SER260
D	SER262
D	LYS263
D	ARG270
D	PHE355
D	ARG399

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	112
Details	Transit peptide: {"description":"Mitochondrion","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	108
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	40
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	20
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9WVM8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	12
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9WVM8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)