4G5F

Pantothenate synthetase in complex with racemate (2S)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID and (2R)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID

Summary for 4G5F

Entry DOI	10.2210/pdb4g5f/pdb
Related	4DDH 4DDK 4DDM 4EF6 4EFK 4FZJ
Descriptor	Pantothenate synthetase, GLYCEROL, (2S)-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid, ... (7 entities in total)
Functional Keywords	alpha beta 3-layer(aba) sandwich rossmann fold, ligase, atp binding pantoate binding beta-alanine binding, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Mycobacterium tuberculosis
Cellular location	Cytoplasm (Potential): P0A5R0
Total number of polymer chains	2
Total formula weight	66355.81
Authors	Silvestre, H.L.,Blundell, T.L.,Abell, C.,Ciulli, A. (deposition date: 2012-07-17, release date: 2013-07-17, Last modification date: 2023-09-13)
Primary citation	Silvestre, H.L.,Blundell, T.L.,Abell, C.,Ciulli, A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proc.Natl.Acad.Sci.USA, 110:12984-12989, 2013 Cited by PubMed: 23872845 DOI: 10.1073/pnas.1304045110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation