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4DDK

Pantothenate synthetase in complex with 1,3-benzodioxole-5-carboxylic acid

Summary for 4DDK
Entry DOI10.2210/pdb4ddk/pdb
Related4DDH 4DDM
DescriptorPantothenate synthetase, 1,3-benzodioxole-5-carboxylic acid, GLYCEROL, ... (6 entities in total)
Functional Keywordsfragment-based drug discovery, alpha beta/adenine nucleotide alpha hydrolase-like, pantoate and b-ala binding, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceMycobacterium tuberculosis
Cellular locationCytoplasm (Potential): P0A5R0
Total number of polymer chains2
Total formula weight64163.33
Authors
Silvestre, H.L. (deposition date: 2012-01-18, release date: 2013-02-13, Last modification date: 2023-09-13)
Primary citationSilvestre, H.L.,Blundell, T.L.,Abell, C.,Ciulli, A.
Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery.
Proc.Natl.Acad.Sci.USA, 110:12984-12989, 2013
Cited by
PubMed: 23872845
DOI: 10.1073/pnas.1304045110
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

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