4EFK

Pantothenate synthetase in complex with N,N-DIMETHYLTHIOPHENE-3-SULFONAMIDE

Summary for 4EFK

Entry DOI	10.2210/pdb4efk/pdb
Related	3IME 4DDH 4DDK 4DDM 4DE5 4EF6
Descriptor	Pantothenate synthetase, N,N-dimethylthiophene-3-sulfonamide, GLYCEROL, ... (7 entities in total)
Functional Keywords	alpha beta/3-layer sandwich/rossmann fold, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Mycobacterium tuberculosis
Cellular location	Cytoplasm (Potential): P0A5R0
Total number of polymer chains	2
Total formula weight	64337.92
Authors	Ciulli, A.,Silvestre, H.L.,Blundell, T.L.,Abell, C. (deposition date: 2012-03-29, release date: 2013-03-13, Last modification date: 2024-02-28)
Primary citation	Silvestre, H.L.,Blundell, T.L.,Abell, C.,Ciulli, A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proc.Natl.Acad.Sci.USA, 110:12984-12989, 2013 Cited by PubMed: 23872845 DOI: 10.1073/pnas.1304045110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation