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4EF6

Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in complex with fragment 1

Summary for 4EF6
Entry DOI10.2210/pdb4ef6/pdb
Related3IME 4DDH 4DDK 4DDM 4DE5
DescriptorPantothenate synthetase, ETHANOL, 3-(1,3-benzodioxol-5-yl)propanoic acid, ... (6 entities in total)
Functional Keywordsalpha beta/3-layer(aba) sandwich/rossmann fold, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceMycobacterium tuberculosis
Cellular locationCytoplasm (Potential): P0A5R0
Total number of polymer chains2
Total formula weight64265.58
Authors
Silvestre, H.L.,Ciulli, A.,Abell, C.,Blundell, T. (deposition date: 2012-03-29, release date: 2013-03-13, Last modification date: 2023-09-13)
Primary citationSilvestre, H.L.,Blundell, T.L.,Abell, C.,Ciulli, A.
Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery.
Proc.Natl.Acad.Sci.USA, 110:12984-12989, 2013
Cited by
PubMed: 23872845
DOI: 10.1073/pnas.1304045110
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.94 Å)
Structure validation

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