4EF6
Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in complex with fragment 1
Summary for 4EF6
Entry DOI | 10.2210/pdb4ef6/pdb |
Related | 3IME 4DDH 4DDK 4DDM 4DE5 |
Descriptor | Pantothenate synthetase, ETHANOL, 3-(1,3-benzodioxol-5-yl)propanoic acid, ... (6 entities in total) |
Functional Keywords | alpha beta/3-layer(aba) sandwich/rossmann fold, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Mycobacterium tuberculosis |
Cellular location | Cytoplasm (Potential): P0A5R0 |
Total number of polymer chains | 2 |
Total formula weight | 64265.58 |
Authors | Silvestre, H.L.,Ciulli, A.,Abell, C.,Blundell, T. (deposition date: 2012-03-29, release date: 2013-03-13, Last modification date: 2023-09-13) |
Primary citation | Silvestre, H.L.,Blundell, T.L.,Abell, C.,Ciulli, A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proc.Natl.Acad.Sci.USA, 110:12984-12989, 2013 Cited by PubMed: 23872845DOI: 10.1073/pnas.1304045110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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