4FRC

Carbonic Anhydrase II in complex with N'-sulfamoylpyrrolidine-1-carboximidamide

Summary for 4FRC

Related3M14 3M04 4FPT 4FU5 4FVN 4FVO
DescriptorCarbonic anhydrase 2, MERCURIBENZOIC ACID, ZINC ION, ... (6 entities in total)
Functional Keywords10 stranded twisted beta-sheets, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P00918
Total number of polymer chains1
Total molecular weight29946.55
Authors
Di Pizio, A.,Heine, A.,Klebe, G. (deposition date: 2012-06-26, release date: 2013-07-17)
Primary citation
Di Pizio, A.,Schulze Wischeler, J.,Haake, M.,Heine, A.,Supuran, C.,Klebe, G.
High resolution crystal structures of Carbonic Anhydrase II in complex with novel sulfamide binders
To be Published,
Experimental method
X-RAY DIFFRACTION (0.98 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.11950 0.5% 0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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170172
PDB entries from 2020-10-21