Carbonic Anhydrase II in complex with N'-sulfamoylpyrrolidine-1-carboximidamide

Summary for 4FRC

Related3M14 3M04 4FPT 4FU5 4FVN 4FVO
DescriptorCarbonic anhydrase 2, MERCURIBENZOIC ACID, ZINC ION, ... (6 entities in total)
Functional Keywords10 stranded twisted beta-sheets, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P00918
Total number of polymer chains1
Total molecular weight29946.55
Di Pizio, A.,Heine, A.,Klebe, G. (deposition date: 2012-06-26, release date: 2013-07-17)
Primary citation
Di Pizio, A.,Schulze Wischeler, J.,Haake, M.,Heine, A.,Supuran, C.,Klebe, G.
High resolution crystal structures of Carbonic Anhydrase II in complex with novel sulfamide binders
To be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.11950 0.5% 0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-21