4FOX

Crystal Structure of Mtb ThyA in complex with dUMP and Raltitrexed

Summary for 4FOX

• Entry DOI: 10.2210/pdb4fox/pdb
• Related: 3QJ7 4FOA 4FOG 4FOX 4FQS
• Descriptor: Thymidylate synthase, TOMUDEX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (4 entities in total)
• Functional Keywords: structural genomics, tb structural genomics consortium, tbsgc, transferase, thymidylate synthase
• Biological source: Mycobacterium tuberculosis
• Cellular location: Cytoplasm (By similarity): P67044
• Total number of polymer chains: 8
• Total formula weight: 245212.00

Authors

Reddy, M.C.M.,Bruning, J.B.,Sacchettini, J.C.,Harshbarger, W.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2012-06-21, release date: 2013-08-07, Last modification date: 2023-09-13)

• Primary citation: Reddy, M.C.M.,Bruning, J.B.,Sacchettini, J.C.,Harshbarger, W.; Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: Insights into the selectivity and mode of inhibition; To be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)