4FO6
Crystal structure of the pre-catalytic ternary complex of polymerase lambda with a dATP analog opposite a templating T and an rCMP at the primer terminus.
Replaces: 3UQ1Summary for 4FO6
Entry DOI | 10.2210/pdb4fo6/pdb |
Related | 3UPQ 3UQ0 3UQ2 |
Descriptor | DNA polymerase lambda, MANGANESE (II) ION, 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine, ... (12 entities in total) |
Functional Keywords | dna polymerase, transferase, lyase-dna complex, lyase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q9UGP5 |
Total number of polymer chains | 6 |
Total formula weight | 46719.16 |
Authors | Gosavi, R.A.,Moon, A.F.,Kunkel, T.A.,Pedersen, L.C.,Bebenek, K. (deposition date: 2012-06-20, release date: 2012-07-11, Last modification date: 2023-09-13) |
Primary citation | Gosavi, R.A.,Moon, A.F.,Kunkel, T.A.,Pedersen, L.C.,Bebenek, K. The catalytic cycle for ribonucleotide incorporation by human DNA Pol lambda Nucleic Acids Res., 40:1-10, 2012 Cited by PubMed: 22584622DOI: 10.1093/nar/gks413 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.007 Å) |
Structure validation
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