3UQ2

Crystal structure of the post-catalytic product complex of polymerase lambda with an rCMP inserted opposite a templating G and dAMP inserted opposite a templating T at the primer terminus.

Summary for 3UQ2

• Entry DOI: 10.2210/pdb3uq2/pdb
• Related: 3MGH 3MGI 3UPQ 3UQ0 3UQ1
• Descriptor: DNA polymerase lambda, 5'-D(*CP*GP*GP*CP*TP*GP*TP*AP*CP*TP*G)-3', 5'-D(*CP*AP*GP*TP*AP)-R(P*CP*A)-3', ... (8 entities in total)
• Functional Keywords: dna polymerase lambda, ribonucleotide incorporation, protein conformation, transferase, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q9UGP5
• Total number of polymer chains: 4
• Total formula weight: 43608.69

Authors

Gosavi, R.A.,Moon, A.F.,Kunkel, T.A.,Pedersen, L.C.,Bebenek, K. (deposition date: 2011-11-18, release date: 2012-05-23, Last modification date: 2023-09-13)

• Primary citation: Gosavi, R.A.,Moon, A.F.,Kunkel, T.A.,Pedersen, L.C.,Bebenek, K.; The catalytic cycle for ribonucleotide incorporation by human DNA Pol lambda; Nucleic Acids Res., 40:7518-7527, 2012; PubMed: 22584622; DOI: 10.1093/nar/gks413

Experimental method

X-RAY DIFFRACTION (2.25 Å)