4FO6

Crystal structure of the pre-catalytic ternary complex of polymerase lambda with a dATP analog opposite a templating T and an rCMP at the primer terminus.

Replaces:  3UQ1

Summary for 4FO6

• Entry DOI: 10.2210/pdb4fo6/pdb
• Related: 3UPQ 3UQ0 3UQ2
• Descriptor: DNA polymerase lambda, MANGANESE (II) ION, 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine, ... (12 entities in total)
• Functional Keywords: dna polymerase, transferase, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q9UGP5
• Total number of polymer chains: 6
• Total formula weight: 46719.16

Authors

Gosavi, R.A.,Moon, A.F.,Kunkel, T.A.,Pedersen, L.C.,Bebenek, K. (deposition date: 2012-06-20, release date: 2012-07-11, Last modification date: 2023-09-13)

• Primary citation: Gosavi, R.A.,Moon, A.F.,Kunkel, T.A.,Pedersen, L.C.,Bebenek, K.; The catalytic cycle for ribonucleotide incorporation by human DNA Pol lambda; Nucleic Acids Res., 40:1-10, 2012; PubMed: 22584622; DOI: 10.1093/nar/gks413

Experimental method

X-RAY DIFFRACTION (2.007 Å)