4FEX

Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor tyrphostin AG1478

4FEX の概要

• エントリーDOI: 10.2210/pdb4fex/pdb
• 関連するPDBエントリー: 4EJ7 4feu 4fev 4few 4GKH 4GKI
• 分子名称: Aminoglycoside 3'-phosphotransferase AphA1-IAB, KANAMYCIN A, N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine, ... (6 entities in total)
• 機能のキーワード: tyrphostin, 4-anilinoquinazoline, tyrphostin ag1478, ag1478, protein kinase inhibitor, center for structural genomics of infectious diseases, csgid, niaid, national institute of allergy and infectious diseases, eukaryotic protein kinase-like fold, alpha/beta protein, transferase, phosphotransferase, aminoglycoside phosphotransferase, antibiotic resistance, aminoglycosides, kanamycin, gtp, intracellular, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Acinetobacter baumannii
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 158901.23

構造登録者

Stogios, P.J.,Evdokimova, E.,Wawrzak, Z.,Minasov, G.,Egorova, O.,Di Leo, R.,Shakya, T.,Spanogiannopoulos, P.,Wright, G.D.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2012-05-30, 公開日: 2012-06-20, 最終更新日: 2023-09-13)

• 主引用文献: Stogios, P.J.,Spanogiannopoulos, P.,Evdokimova, E.,Egorova, O.,Shakya, T.,Todorovic, N.,Capretta, A.,Wright, G.D.,Savchenko, A.; Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.; Biochem.J., 454:191-200, 2013; PubMed: 23758273; DOI: 10.1042/BJ20130317

実験手法

X-RAY DIFFRACTION (2.71 Å)