4FEX
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor tyrphostin AG1478
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Aminoglycoside 3'-phosphotransferase AphA1-IAB | polymer | 272 | 31022.1 | 5 | UniProt (B0VD92) | Acinetobacter baumannii | |
| 2 | F, I, K, N, P (A, B, C, D, E) | KANAMYCIN A | non-polymer | 484.5 | 5 | Chemie (KAN) | |||
| 3 | G, L, O, Q (A, C, D, E) | N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine | non-polymer | 315.8 | 4 | Chemie (0TO) | |||
| 4 | H, J (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | M (C) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 6 | R, S, T, U, V (A, B, C, D, E) | water | water | 18.0 | 174 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 271 (UniProt: B0VD92)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 155110.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3790.5 | |
| All* | Total formula weight | 158901.2 |
