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4FEX

Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor tyrphostin AG1478

Summary for 4FEX
Entry DOI10.2210/pdb4fex/pdb
Related4EJ7 4GKH 4GKI 4feu 4fev 4few
DescriptorAminoglycoside 3'-phosphotransferase AphA1-IAB, KANAMYCIN A, N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine, ... (6 entities in total)
Functional Keywordstyrphostin, 4-anilinoquinazoline, tyrphostin ag1478, ag1478, protein kinase inhibitor, center for structural genomics of infectious diseases, csgid, niaid, national institute of allergy and infectious diseases, eukaryotic protein kinase-like fold, alpha/beta protein, transferase, phosphotransferase, aminoglycoside phosphotransferase, antibiotic resistance, aminoglycosides, kanamycin, gtp, intracellular, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceAcinetobacter baumannii
Total number of polymer chains5
Total formula weight158901.23
Authors
Primary citationStogios, P.J.,Spanogiannopoulos, P.,Evdokimova, E.,Egorova, O.,Shakya, T.,Todorovic, N.,Capretta, A.,Wright, G.D.,Savchenko, A.
Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
Biochem.J., 454:191-200, 2013
Cited by
PubMed: 23758273
DOI: 10.1042/BJ20130317
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.71 Å)
Structure validation

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