4FEX
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor tyrphostin AG1478
Summary for 4FEX
Entry DOI | 10.2210/pdb4fex/pdb |
Related | 4EJ7 4GKH 4GKI 4feu 4fev 4few |
Descriptor | Aminoglycoside 3'-phosphotransferase AphA1-IAB, KANAMYCIN A, N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine, ... (6 entities in total) |
Functional Keywords | tyrphostin, 4-anilinoquinazoline, tyrphostin ag1478, ag1478, protein kinase inhibitor, center for structural genomics of infectious diseases, csgid, niaid, national institute of allergy and infectious diseases, eukaryotic protein kinase-like fold, alpha/beta protein, transferase, phosphotransferase, aminoglycoside phosphotransferase, antibiotic resistance, aminoglycosides, kanamycin, gtp, intracellular, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Acinetobacter baumannii |
Total number of polymer chains | 5 |
Total formula weight | 158901.23 |
Authors | Stogios, P.J.,Evdokimova, E.,Wawrzak, Z.,Minasov, G.,Egorova, O.,Di Leo, R.,Shakya, T.,Spanogiannopoulos, P.,Wright, G.D.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2012-05-30, release date: 2012-06-20, Last modification date: 2023-09-13) |
Primary citation | Stogios, P.J.,Spanogiannopoulos, P.,Evdokimova, E.,Egorova, O.,Shakya, T.,Todorovic, N.,Capretta, A.,Wright, G.D.,Savchenko, A. Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance. Biochem.J., 454:191-200, 2013 Cited by PubMed: 23758273DOI: 10.1042/BJ20130317 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.71 Å) |
Structure validation
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